Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis
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چکیده
منابع مشابه
Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis.
Ovariectomy (OVX) of female rats results in a decreased behavioral response to stimulation of the mesostriatal dopamine (DA) system and decreased striatal DA release in vitro. Estrogen replacement restores both behavioral and neurochemical responsiveness. In this report, microdialysis in freely moving rats is used to simultaneously study the behavioral and neurochemical effects of systemic estr...
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Based upon the observation that estrogen acts in the striatum to rapidly modulate dopamine (DA) neural transmission and DA-mediated behaviors, it has been postulated that these effects of estrogen are mediated by a specific, membrane-bound receptor mechanism. To further characterize the pharmacological specificity of the estrogen binding site, the present experiments examine effects of various ...
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Amphetamine (AMPH)-induced rotational behavior in non-lesioned rats and AMPH-stimulated dopamine (DA) release from striatal tissue fragments in vitro were used to study the long-term effects of a single injection of AMPH on activity in the mesostriatal DA system. A single injection of a low dose of AMPH (1.25 mg/kg) greatly enhanced the rotational behavior produced by a second injection of AMPH...
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Rats depleted of dopamine (DA) by intraventricular 6-hydroxydopamine (6-OHDA) in infancy show behavioral impairments as adults, but their basic sensory-motor functions and feeding abilities are intact; at least relative to the pronounced deficits seen in rats given similar treatment in adulthood. Here we investigate whether presynaptic changes culminating in enhanced DA release are present in a...
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Sex differences are described in both a lateralized behavior (amphetamine-elicited rotation) and in the lateralization of striatal dopamine (DA) content. Amphetamine (AMPH) elicited significantly more partial turns, total rotations and lateralized (net) rotations in female, than in male rats. The two sexes also differed in their pattern of net rotations over time. In females, but not males, the...
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ژورنال
عنوان ژورنال: Neuroscience Letters
سال: 1990
ISSN: 0304-3940
DOI: 10.1016/0304-3940(90)90618-j